%0 Journal Article
%T SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL SCREENING OF VARIOUS N-SUBSTITUTED DERIVATIVES OF SULFONAMIDES
%A AZIZ-UR-REHMAN
%A WAJEEHA TANVEER
%A MUHAMMAD ATHAR ABBASI
%A SUMBAL AFROZ
%A KHALID MOHAMMED KHAN
%A MUHAMMAD ASHRAF
%A AND IFTIKHAR AFZAL
%J International Journal of Chemical Research
%D 2011
%I Bioinfo Publications
%X In the present study, a series of N-substituted sulfonamides have been synthesized. The reaction ofbenzene sulfonyl chloride (1) with O-anisidine (2) yielded N-(2-methoxyphenyl) benzenesulfonamide (3), which onbromination with bromine in the presence of acetic acid gave N-(4,5-dibromo-2-methoxyphenyl)benzenesulfonamide(6). The two products (3) and (6) further on treatment with alkyl halides/acyl halide in the presence of sodium hydrideyielded thirteen different N-substituted sulfonamides. The compounds were characterized by IR, EIMS and 1H-NMRand screened against acetyl cholinesterase, butyryl cholinesterase and lipoxygenase enzymes. The results revealedthat N-butyl-N-(4, 5-dibromo-2-methoxyphenyl)benzene sulfonamide (6d) and N-pentyl-N-(4,5-dibromo-2-methoxyphenyl)benzenesulfonamide (6e) exhibited good inhibitory potential against lipoxygenase.
%K O-anisodine
%K Sulfonamide
%K butyryl cholinesterase
%K lipoxygenase and 1H-NMR
%U http://www.bioinfo.in/uploadfiles/13243640443_3_6_IJCR.pdf