SYNTHESIS, ANTI-INFLAMMATORY AND ANTI-MICROBIAL ACTIVITY OF PYRIMIDINE-5-CARBOXYLATE DERIVATIVES

Ethyl-2-amino-4-chloro-6-(2, 4, 6 trichloro phenyl amino) pyrimidine-5-carboxylate and ethyl-2-amino 4-chloro-1, 3-dimethyl-6-(phenyl amino)-1,2,3,4 tetrahydro pyrimidine-5- carboxylate derivatives were synthesized through Cyclocondensation and Michel type of addition reaction with the aromatic anilines, guanidine and benzamidines. Synthesized novel derivatives were confirmed by elemental analysis viz., IR, 1HNMR and Mass spectroscopy. These novel derivatives have been screened for Antibacterial, Antifungal and Antiinflammatory activity.