Ayur-informatics: Establishing an in-silico-ayurvedic medication for Alzheimer’s disease

Alzheimer’s disease is an incurable, degenerative, and terminal disease. It is associated withmutations in Amyloid Precursor Protein (APP), Presenilin 1 (PS1), Presenilin 2 (PS2), or Apolipoprotein E(APOE). 3D structures of these 4 proteins were generated using Homology Modeling. Active compounds ofmedicinal herbs- Canscora decussate, Nardostachys jatamansi and Mucuna pruriens were selected asthese three herbs have properties of memory enhancement. Chemical structures of the active component ofthese herbs were drawn using chemsketch, combined & converted to *.pdb. The four proteins weresuccessfully docked with Canscora decussate- Nardostachys jatamansi –Mucuna pruriens’s activecomponent combination.