%0 Journal Article
%T Ayur-informatics: Establishing an in-silico-ayurvedic medication for Alzheimer¡¯s disease
%A Mohini Gore
%A Preenon Bagchi
%A Desai N.S.
%A Ajit Kar
%J International Journal of Bioinformatics Research
%D 2010
%I Bioinfo Publications
%X Alzheimer¡¯s disease is an incurable, degenerative, and terminal disease. It is associated withmutations in Amyloid Precursor Protein (APP), Presenilin 1 (PS1), Presenilin 2 (PS2), or Apolipoprotein E(APOE). 3D structures of these 4 proteins were generated using Homology Modeling. Active compounds ofmedicinal herbs- Canscora decussate, Nardostachys jatamansi and Mucuna pruriens were selected asthese three herbs have properties of memory enhancement. Chemical structures of the active component ofthese herbs were drawn using chemsketch, combined & converted to *.pdb. The four proteins weresuccessfully docked with Canscora decussate- Nardostachys jatamansi ¨CMucuna pruriens¡¯s activecomponent combination.
%K Alzheimer¡¯s disease
%K Ayurveda
%K Canscora decussate
%K Nardostachys jatamansi
%K Mucuna pruriens
%K Drug designing
%U http://www.bioinfo.in/uploadfiles/12695767212_1_6_IJBR.pdf