Design; Synthesis and Antihypertensive activity of 4'-(2-{2-[(2-chloro-benzylidene)-amino]-phenyl}-5-nitro-benzoimidazol-1-ylmethyl)] biphenyl-2-carboxylic acid

In the present study, a series of 4`-(2-{2-[(2-chloro-benzylidene)-amino]-phenyl}-5-nitro-benzoimidazol-1-ylmethyl)] biphenyl-2-carboxylic acid derivatives are synthesized by A one-step coupling of substituted benzimidazoles with biphenyl carboxylic moiety mediated by potassium carbonate is described. The biphenyl carboxylic moiety was prepared from 9-H-fluorenone and substituted benzimidazoles were synthesized from o-phenylenediamine with anthranilic acid. Keywords: Benzimidazoles, biphenyl-2-carboxylic acid, angiotensin II, hypertension