%0 Journal Article
%T Design; Synthesis and Antihypertensive activity of 4'-(2-{2-[(2-chloro-benzylidene)-amino]-phenyl}-5-nitro-benzoimidazol-1-ylmethyl)] biphenyl-2-carboxylic acid
%A M. C. Sharma
%A D.V. Kohli
%A Smita Sharma
%J International Journal of Advances in Pharmaceutical Sciences
%D 2011
%I 
%R 10.5138/174
%X In the present study, a series of 4`-(2-{2-[(2-chloro-benzylidene)-amino]-phenyl}-5-nitro-benzoimidazol-1-ylmethyl)] biphenyl-2-carboxylic acid derivatives are synthesized by A one-step coupling of substituted benzimidazoles with biphenyl carboxylic moiety mediated by potassium carbonate is described. The biphenyl carboxylic moiety was prepared from 9-H-fluorenone and substituted benzimidazoles were synthesized from o-phenylenediamine with anthranilic acid. Keywords: Benzimidazoles, biphenyl-2-carboxylic acid, angiotensin II, hypertension
%K Benzimidazoles
%K biphenyl-2-carboxylic acid
%K angiotensin II
%K hypertension
%U http://www.arjournals.org/index.php/ijaps/article/view/174