Synthesis of Novel 1,2,3,4-Tetrahydro-N-(Substitutedphenyl)-6-Methyl-4-(4-(Phenoxymethyl)Phenyl)-2-Thioxopyrimidine-5-Carboxamide and Study of their Antimicrobial Activity

During the last two decades, several pyrimidine derivatives have been developed as chemotherapeutic agents and have found wide clinical applications. We synthesize some pyrimidines by Biginelli condensation method. Novel 1,2,3,4-tetrahydro-N-(substitutedphenyl)-6-methyl-4-(4-(phenoxymethyl)phenyl)-2-thioxopyrimidine-5-carboxamide (AB116 to AB130) are synthesized and characterized by FT-IR, 1H NMR, Mass spectra, TLC and elemental analysis. The newly synthesized compounds were screened for antimicrobial activities(MIC) in vitro against two strains of gram –ve and two strains of gram +ve bacteria and three fungi by broth dilution method. Few of the compounds show excellent antimicrobial activity.