%0 Journal Article
%T Synthesis of Novel 1,2,3,4-Tetrahydro-N-(Substitutedphenyl)-6-Methyl-4-(4-(Phenoxymethyl)Phenyl)-2-Thioxopyrimidine-5-Carboxamide and Study of their Antimicrobial Activity
%A Atul D. Baldev
%A Mahendra G. Borisagar
%A Kartik Vyas
%A Kiran Nimavat
%J International Journal For Pharmaceutical Research Scholars
%D 2012
%I International Journals for Pharmaceutical Research Scholars
%X During the last two decades, several pyrimidine derivatives have been developed as chemotherapeutic agents and have found wide clinical applications. We synthesize some pyrimidines by Biginelli condensation method. Novel 1,2,3,4-tetrahydro-N-(substitutedphenyl)-6-methyl-4-(4-(phenoxymethyl)phenyl)-2-thioxopyrimidine-5-carboxamide (AB116 to AB130) are synthesized and characterized by FT-IR, 1H NMR, Mass spectra, TLC and elemental analysis. The newly synthesized compounds were screened for antimicrobial activities(MIC) in vitro against two strains of gram ¨Cve and two strains of gram +ve bacteria and three fungi by broth dilution method. Few of the compounds show excellent antimicrobial activity.
%K 1
%K 2
%K 3
%K 4-tetrahydro pyrimidine
%K Antimicrobial activity
%U http://www.ijprs.com/download.php?file=1344006652.pdf