Synthesis, Characterization and Antimicrobial Activity of Methyl 1-(-2-amine-alkylcarbonyl) piperidine-4-carboxylate

A series of Methyl 1-(-2-amine-alkylcarbonyl) piperidine-4-carboxylate derivatives of amino acids (3ae)was synthesized. These new derivative was achieved by treating Isonipecotic acid methyl ester (1)with Boc-protected amino acids (2a-e) using CDI as coupling reagent in MDC at room temperature.Further deprotection with HCl/Dioxane gives the desired product. Structures of the synthesizedcompounds were established on the basis of spectral and elemental analysis. The synthesizedcompounds were screened for antimicrobial activity.