%0 Journal Article
%T Synthesis, Characterization and Antimicrobial Activity of Methyl 1-(-2-amine-alkylcarbonyl) piperidine-4-carboxylate
%A Bhatt ND
%A Nimavat K
%J International Journal For Pharmaceutical Research Scholars
%D 2013
%I International Journals for Pharmaceutical Research Scholars
%X A series of Methyl 1-(-2-amine-alkylcarbonyl) piperidine-4-carboxylate derivatives of amino acids (3ae)was synthesized. These new derivative was achieved by treating Isonipecotic acid methyl ester (1)with Boc-protected amino acids (2a-e) using CDI as coupling reagent in MDC at room temperature.Further deprotection with HCl/Dioxane gives the desired product. Structures of the synthesizedcompounds were established on the basis of spectral and elemental analysis. The synthesizedcompounds were screened for antimicrobial activity.
%K Protected amino acid
%K Isonipecotic acid
%K CDI
%K antimicrobial activity
%U http://www.ijprs.com/download.php?file=1365857800.pdf