Computer-based modeling for sugar preferences of an oxidoreducatse from Arthrobacter nicotinovorans Pao1 plasmid

The pAO1 megaplasmid of Arthrobacter nicotinovorans encodes two different pathways: one for nicotine metabolism and an putative sugar catabolic pathway. Using computational methods, the preferences for sugar of an oxidoreductase from the megaplasmid was addressed. The experimental and modeling data showed that the enzyme is tetrameric, has an ligand binding place close to the EKP conserved sequence and might prefer as substrate ketohexoses.