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Infectio  2012 

Biology of Trypanosoma cruzi: An update Biología del Trypanosoma cruzi: Actualización

Keywords: Trypanosoma cruzi , biologia , transcriptoma , proteoma , Trypanosoma cruzi , biology , transcriptome , proteome

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Abstract:

Chagas disease, an illness caused by the protozoan Trypanosoma cruzi, is clinically and epidemiologically important in Latin America, and particularly in Brazil. This article presents the main biological characteristics of Trypanosoma cruzi, emphasizing ultrastructural, morphological, evolutionary, transcriptomic, and proteomic aspects. With this purpose a literature review was conducted, which allowed for the construction of different sections of the text. The efforts to expand the knowledge of this protist biology may bring positive implications for the understanding of the pathogenesis, control, and above all, treatment of patients affected by this disease. A moléstia de Chagas, enfermidade causada pelo protozoário Trypanosoma cruzi, apresenta grande relevancia clínica e epidemiológica na America Latina, com destaque para o Brasil. Neste artigo ser o apresentadas as principais características biológicas do Trypanosoma cruzi, enfatizando-se os aspectos ultra-estruturais, morfológicos, evolutivos, transcript micos e prote micos. Para tanto, foi realizada revis o da literatura, a qual subsidiou a constru o de diferentes se es do texto. As investidas para ampliar o conhecimento acerca da biologia do protista poder o trazer implica es positivas para a compreens o da patogênese, do controle e, sobretudo, do tratamento dos pacientes portadores da moléstia.

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