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Evaluation of central nervous system depressant activity of Cleome rutidosperma

DOI: 10.4081/ams.2012.e8

Keywords: Cleome rutidosperma , CNS , anticonvulsant , potentiation , muscle relaxant , anti-anxiety

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Abstract:

The central nervous system (CNS) depressant activity of the ethanol extract (200 and 400 mg/kg) and its fractions (200 mg/kg each) of the aerial parts of Cleome rutidosperma was investigated in various models. The tested extract and its fractions showed significant (P<0.01) anxiolytic, anticonvulsant activity (in treating petit mal epilepsy) without any unwanted sedation effect. These findings justify the traditional use of this plant in CNS disorders.

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