Prognostic significance of NF-kB in resectable gastric cancer treated with

OBJECTIVES: The aim of this study is to determine the prognostic value of transcription factor nucleer factor kappa B (NF-kB) in resectable gastric cancer patients treated with concurrent chemoradiotherapy. METHODS: Forty-nine (35 males, 14 females; median age 55; range 22-73 years) resectable gastric cancer patients treated with gastrectomy and adjuvant concurrent chemoradiotherapy were enrolled in this study. All patients received weekly 250 mg/m2 5-FU chemotherapy and radiotherapy concomittantly after gastrectomy. Then patients received 4 cycles i.v bolus FUFA chemotherapy sequentialy as consolidation treatment 2-4 week after chemoradiotherapy. Immunohistochemistry staining was performed on paraffin embedded tissue. NF-kB monoclonal antibodies were used for the staining. RESULTS: The progression free survival and overall survival diference were analised between NF-kB positive and negative groups. For NF-kB a specimen was judged positive if more than 10% of the total cancer cells in a single field of view showed a response. CONCLUSION: In patients who NF-kB was stained more than 10%, the overall survival was worse and there was statistically significant difference between groups. But in two groups, no statistically significant difference due to disease free survival.