%0 Journal Article
%T Prognostic significance of NF-kB in resectable gastric cancer treated with
%A O£¿uz Galip YILDIZ
%A Serdar SOYUER
%A I£¿£¿n SOYUER
%A Kadir U£¿AR
%J Turkish Journal of Oncology
%D 2007
%I KARE Publishing
%X OBJECTIVES: The aim of this study is to determine the prognostic value of transcription factor nucleer factor kappa B (NF-kB) in resectable gastric cancer patients treated with concurrent chemoradiotherapy. METHODS: Forty-nine (35 males, 14 females; median age 55; range 22-73 years) resectable gastric cancer patients treated with gastrectomy and adjuvant concurrent chemoradiotherapy were enrolled in this study. All patients received weekly 250 mg/m2 5-FU chemotherapy and radiotherapy concomittantly after gastrectomy. Then patients received 4 cycles i.v bolus FUFA chemotherapy sequentialy as consolidation treatment 2-4 week after chemoradiotherapy. Immunohistochemistry staining was performed on paraffin embedded tissue. NF-kB monoclonal antibodies were used for the staining. RESULTS: The progression free survival and overall survival diference were analised between NF-kB positive and negative groups. For NF-kB a specimen was judged positive if more than 10% of the total cancer cells in a single field of view showed a response. CONCLUSION: In patients who NF-kB was stained more than 10%, the overall survival was worse and there was statistically significant difference between groups. But in two groups, no statistically significant difference due to disease free survival.
%K Chemoradiotherapy
%K gastric cancer/patoloji
%K immunohistochemistry
%K NF-kappa B
%K prognostic factor
%K survival rate.
%U http://onkder.org/pdf.php3?id=633