Simple Spectrophotometric determination of Tegaserod Maleate in Pharmaceutical dosage forms

Plan: An analytical method for the estimation of Tegaserod Maleatein bulk drugs and pharmaceutical dosage forms is described.Prologue: Tegaserod Maleate is the first selective serotonin 5-HT4receptor partial agonist to improve symptoms of constipation-predominantIrritable Bowel syndrome. The present study aims at the development of simpleSpectrophotometric method for the estimation of Tegaserod in dosage forms.Methodology: The developed method is based on the formation of a purplecoloured complex due to the reaction of Tegaserod Maleate withp-Dimethylaminobenzaldehyde reagent, which gave a maximum absorbance at 515nm.Beer’s law is obeyed over the concentration range of 5-50μg/ml. All thevariables were studied to optimize the reaction conditions.Outcome: The proposed method is simple, fast, accurate and economical and can be used for the routine analysis of Tegaserod in dosage forms.