%0 Journal Article
%T Simple Spectrophotometric determination of Tegaserod Maleate in Pharmaceutical dosage forms
%A Helen William
%A Bijumol C
%A Jose Kurien and Thomas Kurian
%J Hygeia : Journal for Drugs and Medicines
%D 2013
%I 
%X Plan: An analytical method for the estimation of Tegaserod Maleatein bulk drugs and pharmaceutical dosage forms is described.Prologue: Tegaserod Maleate is the first selective serotonin 5-HT4receptor partial agonist to improve symptoms of constipation-predominantIrritable Bowel syndrome. The present study aims at the development of simpleSpectrophotometric method for the estimation of Tegaserod in dosage forms.Methodology: The developed method is based on the formation of a purplecoloured complex due to the reaction of Tegaserod Maleate withp-Dimethylaminobenzaldehyde reagent, which gave a maximum absorbance at 515nm.Beer¡¯s law is obeyed over the concentration range of 5-50¦̀g/ml. All thevariables were studied to optimize the reaction conditions.Outcome: The proposed method is simple, fast, accurate and economical and can be used for the routine analysis of Tegaserod in dosage forms.
%K Tegaserod Maleate
%K p-Dimethylaminobenzaldehyde
%K Spectrophotometric method
%U http://www.hygeiajournal.com/Downloads/19294899258.Hellen%20williamTegaseod%20Final.pdf