Necrosis cutánea por warfarina Warfarin-Induced skin necrosis

La necrosis cutánea por warfarina aparece entre 0.01-0.1% de los pacientes, afecta más a mujeres con obesidad y antecedentes de enfermedad tromboembólica luego del quinto día de su inicio. Se debe a un imbalance transitorio de los sistemas anticoagulante y procoagulante, caracterizado por flictenas hemorrágicas en zonas con tejido graso. Reportamos el caso de una necrosis cutánea por warfarina con un desenlace fatal. (Acta Med Colomb 2012; 37: 138-141). Warfarin-induced skin necrosis appears between 0.01% to 0.1% of patients. It affects mostly women with obesity and a history of thromboembolic disease after the fifth day of its administration, and is caused by a transient imbalance of procoagulant and anticoagulant systems, characterized by hemorrhagic blisters in areas with fatty tissue. (Acta Med Colomb 2012; 37: 138-141). We report the case of a warfarin-induced skin necrosis with fatal outcome.