DIVERSE REACTIONS OF )/β-MERCAPTOALKANOIC ACIDS: IN THE SYNTHESES OF CONDENSED FUSED POLYCYCLIC HETEROCYCLES DIVERSE REAKTIONEN VON) / β-Mercaptoalkans ure ACIDS: In den Synthesen von CONDENSED polycyclischen HETEROCYCLEN

This review describes the reactions of β-mercaptoalkanoic acids as building blocks for the synthesis of polyfunctional heterocycles with pharmacological interest. Annelated heterocycles have been prepared by the cyclocondensation reaction of β-mercaptoalkanoic acids with carbonyl function. This reaction takes place by nucleophilic addition, followed by cyclisation with elimination of water. The main objective of this survey is to provide a comprehensive account of the reactions of β-mercaptoalkanoic acids with carbonyl function, halovinylaldehydes, haloesters, heteroaromatic halides, halonitriles, imines in building various heterocycles and examining their potential in developing better chemotherapeutic agents