Prognostic impact of CD57, CD68, M-CSF, CSF-1R, Ki67 and TGF-beta in soft tissue sarcomas

Tissue microarrays from 249 patients with non-gastrointestinal (non-GIST) STS were constructed from duplicate cores of viable and representative neoplastic tumor areas and duplicate cores of peritumoral capsule. Immunohistochemistry was used to evaluate the expression of CD68, M-CSF, CSF-1R, CD57, TGF-beta and Ki67 in tumor and peritumoral capsule.In univariate analyses increased expression of M-CSF (P？=？0.034), Ki67 (P？<？0.001) and TGF-beta (P？=？0.003) in tumor correlated with shorter disease-specific survival (DSS). Increased expression of CD68 in tumor correlated significantly with malignancy grade (P？=？0.016), but not DSS (P？=？0.270). Increased expression of Ki67 in peritumoral capsule tended to correlate with a shorter DSS (P？=？0.057). In multivariate analyses, co-expression of M-CSF and TGF-beta (P？=？0.022) in tumor and high expression of Ki67 (P？=？0.019) in peritumoral capsule were independent negative prognostic factors for DSS.Increased co-expression of M-CSF and TGF-beta in tumor in patients with STS, and increased expression of Ki67 in peritumoral capsule were independent negative prognostic factors for DSS.