%0 Journal Article
%T Prognostic impact of CD57, CD68, M-CSF, CSF-1R, Ki67 and TGF-beta in soft tissue sarcomas
%A Sveinung W Sorbye
%A Thomas K Kilvaer
%A Andrej Valkov
%A Tom Donnem
%A Eivind Smeland
%A Khalid Al-Shibli
%A Roy M Bremnes
%A Lill-Tove Busund
%J BMC Clinical Pathology
%D 2012
%I BioMed Central
%R 10.1186/1472-6890-12-7
%X Tissue microarrays from 249 patients with non-gastrointestinal (non-GIST) STS were constructed from duplicate cores of viable and representative neoplastic tumor areas and duplicate cores of peritumoral capsule. Immunohistochemistry was used to evaluate the expression of CD68, M-CSF, CSF-1R, CD57, TGF-beta and Ki67 in tumor and peritumoral capsule.In univariate analyses increased expression of M-CSF (P£¿=£¿0.034), Ki67 (P£¿<£¿0.001) and TGF-beta (P£¿=£¿0.003) in tumor correlated with shorter disease-specific survival (DSS). Increased expression of CD68 in tumor correlated significantly with malignancy grade (P£¿=£¿0.016), but not DSS (P£¿=£¿0.270). Increased expression of Ki67 in peritumoral capsule tended to correlate with a shorter DSS (P£¿=£¿0.057). In multivariate analyses, co-expression of M-CSF and TGF-beta (P£¿=£¿0.022) in tumor and high expression of Ki67 (P£¿=£¿0.019) in peritumoral capsule were independent negative prognostic factors for DSS.Increased co-expression of M-CSF and TGF-beta in tumor in patients with STS, and increased expression of Ki67 in peritumoral capsule were independent negative prognostic factors for DSS.
%K Soft tissue sarcomas
%K STS
%K Malignancy grade
%K DSS
%K Macrophages
%K NK cells
%K CD57
%K Ki67
%K TGF-beta
%K TMA
%U http://www.biomedcentral.com/1472-6890/12/7/abstract