Biomarcadores na encefalopatia séptica: revis o sistemática dos estudos clínicos Biomarkers in septic encephalopathy: a systematic review of clinical studies

OBJETIVO: O objetivo deste estudo foi revisar sistematicamente a importancia da enolase específica neuronal e S100B para diagnóstico e monitoriza o da encefalopatia séptica. MéTODOS: Foi realizada uma busca no banco de dados PubMed selecionando estudos que avaliaram níveis séricos de S 100 B e enolase específica neuronal em pacientes com sepse, publicados entre Janeiro de 2000 e Abril de 2012. Apenas estudos em humanos e que utilizaram um método adicional de avalia o neurológica foram selecionados. RESULTADOS: Foram identificados nove estudos, dos quais sete associaram concentra es elevadas de S100 beta e enolase específica neuronal ao desenvolvimento de encefalopatia séptica; quatro também as associaram ao aumento de mortalidade. Entretanto, dois trabalhos n o encontraram essa associa o quando avaliaram S100 beta e um deles n o observou correla o entre a enolase específica neuronal e encefalopatia séptica. CONCLUS O: A S100 beta e enolase específica neuronal s o biomarcadores promissores para diagnóstico e monitoriza o de pacientes com encefalopatia séptica, mas é necessária uma maior investiga o. OBJECTIVE: The aim of this study was to systematically review the importance of neuron-specific enolase and S100 beta for diagnosing and monitoring septic encephalopathy. METHODS: A PubMed database search was performed to identify studies that evaluated S100 beta and neuron-specific enolase serum levels in patients with sepsis and that were published between January 2000 and April 2012. Only human studies that employed an additional method of neurological assessment were selected. RESULTS: Nine studies were identified, seven of which associated high concentrations of S100 beta and neuron-specific enolase with the development of septic encephalopathy. Four studies also associated these concentrations with increased mortality. However, two studies did not find such an association when they evaluated S100 beta levels, and one of these studies did not observe a correlation between neuron-specific enolase and septic encephalopathy. CONCLUSION: S100 beta and neuron-specific enolase are promising biomarkers for diagnosing and monitoring patients with septic encephalopathy, but more research is necessary.