%0 Journal Article
%T Biomarcadores na encefalopatia s¨¦ptica: revis o sistem¨¢tica dos estudos cl¨ªnicos Biomarkers in septic encephalopathy: a systematic review of clinical studies
%A Paula Veriato Zenaide
%A Dimitri Gusmao-Flores
%J Revista Brasileira de Terapia Intensiva
%D 2013
%I Associa??o de Medicina Intensiva Brasileira
%X OBJETIVO: O objetivo deste estudo foi revisar sistematicamente a importancia da enolase espec¨ªfica neuronal e S100B para diagn¨®stico e monitoriza  o da encefalopatia s¨¦ptica. M¨¦TODOS: Foi realizada uma busca no banco de dados PubMed selecionando estudos que avaliaram n¨ªveis s¨¦ricos de S 100 B e enolase espec¨ªfica neuronal em pacientes com sepse, publicados entre Janeiro de 2000 e Abril de 2012. Apenas estudos em humanos e que utilizaram um m¨¦todo adicional de avalia  o neurol¨®gica foram selecionados. RESULTADOS: Foram identificados nove estudos, dos quais sete associaram concentra  es elevadas de S100 beta e enolase espec¨ªfica neuronal ao desenvolvimento de encefalopatia s¨¦ptica; quatro tamb¨¦m as associaram ao aumento de mortalidade. Entretanto, dois trabalhos n o encontraram essa associa  o quando avaliaram S100 beta e um deles n o observou correla  o entre a enolase espec¨ªfica neuronal e encefalopatia s¨¦ptica. CONCLUS O: A S100 beta e enolase espec¨ªfica neuronal s o biomarcadores promissores para diagn¨®stico e monitoriza  o de pacientes com encefalopatia s¨¦ptica, mas ¨¦ necess¨¢ria uma maior investiga  o. OBJECTIVE: The aim of this study was to systematically review the importance of neuron-specific enolase and S100 beta for diagnosing and monitoring septic encephalopathy. METHODS: A PubMed database search was performed to identify studies that evaluated S100 beta and neuron-specific enolase serum levels in patients with sepsis and that were published between January 2000 and April 2012. Only human studies that employed an additional method of neurological assessment were selected. RESULTS: Nine studies were identified, seven of which associated high concentrations of S100 beta and neuron-specific enolase with the development of septic encephalopathy. Four studies also associated these concentrations with increased mortality. However, two studies did not find such an association when they evaluated S100 beta levels, and one of these studies did not observe a correlation between neuron-specific enolase and septic encephalopathy. CONCLUSION: S100 beta and neuron-specific enolase are promising biomarkers for diagnosing and monitoring patients with septic encephalopathy, but more research is necessary.
%K Sepse
%K Encefalopatias
%K Marcadores biol¨®gicos
%K Prote¨ªnas S100
%K Fosfopiruvato hidratase
%K Terapia intensiva
%K Sepsis
%K Brain diseases
%K Biological markers
%K S100 proteins
%K Phosphopyruvate hydratase
%K Intensive care
%U http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-507X2013000100011