Role Of Mast Cell In Oral Pathology

Mast cells in oral tissues releases various pro-inflammatory cytokine tumor necrosis factor alpha (TNF- ) which promotes leukocyte infiltration in various inflammatory condition of oral cavity such as oral lichen planus (OLP), periapical lesions, gingivitis & periodontitis. T lymphocyte derived cytokines influences mast cell migration & mediator release. Mast cell secreted proteases, activates matrix-metalloprotinases-9 (MMP-9) which may contribute to alteration in basement membrane in inflammatory condition such as Lichen Planus. Hence by understanding the role of mast cells in the pathogenesis of various diseases; therapies should be targeted to enhance the prognosis of the diseases.