%0 Journal Article
%T Role Of Mast Cell In Oral Pathology
%A Supriya Kheur
%A Deepali Patekar
%A Neeta Bagul
%A Meena Kulkarni
%J Oral & Maxillofacial Pathology Journal
%D 2013
%I Kairali Society of Oral & Maxillofacial Pathologists
%X Mast cells in oral tissues releases various pro-inflammatory cytokine tumor necrosis factor alpha (TNF- ) which promotes leukocyte infiltration in various inflammatory condition of oral cavity such as oral lichen planus (OLP), periapical lesions, gingivitis & periodontitis. T lymphocyte derived cytokines influences mast cell migration & mediator release. Mast cell secreted proteases, activates matrix-metalloprotinases-9 (MMP-9) which may contribute to alteration in basement membrane in inflammatory condition such as Lichen Planus. Hence by understanding the role of mast cells in the pathogenesis of various diseases; therapies should be targeted to enhance the prognosis of the diseases.
%K Mast cells
%K Degranulation
%K Cytokines
%K Tryptase
%K Chymase.
%U http://a4add.com/remoteupload/uploads/2040/share/13570502032080_myfile.pdf