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色谱  2010 

Simultaneous determination of three components in Pediatric Paracetamol and Amantadine Hydrochloride Granules using high performance liquid chromatography with gradient elution and dual wavelength detection
高效液相色谱-双波长检测-梯度洗脱法同时测定小儿氨酚烷胺颗粒中的3种有效组分

Keywords: high performance liquid chromatography (HPLC),dual wavelength detection,paracetamol,caffeine,chlorphenamine maleate,Pediatric Paracetamol and Amantadine Hydrochloride Granules
高效液相色谱
,双波长检测,对乙酰氨基酚,咖啡因,马来酸氯苯那敏,小儿氨酚烷胺颗粒

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Abstract:

A high performance liquid chromatographic (HPLC) method was developed for the simultaneous determination of paracetamol, caffeine and chlorphenamine maleate in Pediatric Paracetamol and Amantadine Hydrochloride Granules. The separation was performed on a Diamonsil C18 column with 0.1% triethylamine aqueous solution (adjusted pH to 3.7±0.5) and acetonitrile as the mobile phase of gradient elution at a flow rate of 1.0 mL/min. The detection wavelengths were set at 280 nm and 210 nm. The linearities were wide (2.4~60, 0.14~3.6, 0.019~0.48 μg for paracetamol, caffeine and chlorphenamine maleate, respectively)and the average recoveries were not less than 99.0%. The method is simple, accurate and reproducible. It is a good method for the quality control of Pediatric Paracetamol and Amantadine Hydrochloride Granules.

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