%0 Journal Article
%T Simultaneous determination of three components in Pediatric Paracetamol and Amantadine Hydrochloride Granules using high performance liquid chromatography with gradient elution and dual wavelength detection<br>高效液相色谱-双波长检测-梯度洗脱法同时测定小儿氨酚烷胺颗粒中的3种有效组分
%A ZHANG Yihua
%A JIANG Jianguo
%A HAN Xuejing
%A ZHANG Shiliang
%A <br>张轶华
%A 姜建国
%A 韩学静
%A 张世亮
%J 色谱
%D 2010
%I 
%X A high performance liquid chromatographic (HPLC) method was developed for the simultaneous determination of paracetamol, caffeine and chlorphenamine maleate in Pediatric Paracetamol and Amantadine Hydrochloride Granules. The separation was performed on a Diamonsil C18 column with 0.1% triethylamine aqueous solution (adjusted pH to 3.7±0.5) and acetonitrile as the mobile phase of gradient elution at a flow rate of 1.0 mL/min. The detection wavelengths were set at 280 nm and 210 nm. The linearities were wide (2.4~60, 0.14~3.6, 0.019~0.48 μg for paracetamol, caffeine and chlorphenamine maleate, respectively)and the average recoveries were not less than 99.0%. The method is simple, accurate and reproducible. It is a good method for the quality control of Pediatric Paracetamol and Amantadine Hydrochloride Granules.
%K high performance liquid chromatography (HPLC)
%K dual wavelength detection
%K paracetamol
%K caffeine
%K chlorphenamine maleate
%K Pediatric Paracetamol and Amantadine Hydrochloride Granules<br>高效液相色谱
%K 双波长检测
%K 对乙酰氨基酚
%K 咖啡因
%K 马来酸氯苯那敏
%K 小儿氨酚烷胺颗粒
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=6E709DC38FA1D09A4B578DD0906875B5B44D4D294832BB8E&cid=6579068328FE643F&jid=4D81E042D77AFEC6881D14759692069C&aid=696847CC328CE36D1ECB29618637E615&yid=140ECF96957D60B2&vid=D3E34374A0D77D7F&iid=F3090AE9B60B7ED1&sid=67C739DC23BADF58&eid=82BCA4C44409DD5C&journal_id=1000-8713&journal_name=色谱&referenced_num=0&reference_num=0