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色谱  2010 

Enantiomeric separation of azelnidipine by high performance liquid chromatography with chiral stationary phase
高效液相色谱手性固定相法拆分阿折地平对映体

Keywords: high performance liquid chromatography (HPLC),chiral stationary phase,chiral split,azelnidipine
高效液相色谱法
,手性固定相,手性拆分,阿折地平

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Abstract:

A high performance liquid chromatographic (HPLC) method was established for the enantiomeric separation of azelnidipine.Baseline chiral separation of azelnidipine was achieved under normal-phase chromatographic mode using the Chiralpak AD-H chiral column (250 mm×4.6 mm,5.0 μm,Daicel).The influences of the nature of chiral stationary phase,form of the mobile phase,and column temperature on the enantiomeric separation were studied.The optimized chromatographic conditions were hexane-isopropyl alcohol (90∶10,v/v) as the mobile phase with a flow rate of 0.8 mL/min and detection at the wavelength of 254 nm.The column temperature was set at 20 ℃.The resolution of 3.3 for azelnidipine was achieved under the above chromatographic conditions.The method is simple,rapid and with good reproducibility.

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