%0 Journal Article
%T Enantiomeric separation of azelnidipine by high performance liquid chromatography with chiral stationary phase<br>高效液相色谱手性固定相法拆分阿折地平对映体
%A ZHANG Kai
%A XUE Na
%A LI Lin
%A LI Fan
%A DU Yumin
%A <br>张恺
%A 薛娜
%A 李林
%A 李凡
%A 杜玉民
%J 色谱
%D 2010
%I 
%X A high performance liquid chromatographic (HPLC) method was established for the enantiomeric separation of azelnidipine.Baseline chiral separation of azelnidipine was achieved under normal-phase chromatographic mode using the Chiralpak AD-H chiral column (250 mm×4.6 mm,5.0 μm,Daicel).The influences of the nature of chiral stationary phase,form of the mobile phase,and column temperature on the enantiomeric separation were studied.The optimized chromatographic conditions were hexane-isopropyl alcohol (90∶10,v/v) as the mobile phase with a flow rate of 0.8 mL/min and detection at the wavelength of 254 nm.The column temperature was set at 20 ℃.The resolution of 3.3 for azelnidipine was achieved under the above chromatographic conditions.The method is simple,rapid and with good reproducibility.
%K high performance liquid chromatography (HPLC)
%K chiral stationary phase
%K chiral split
%K azelnidipine<br>高效液相色谱法
%K 手性固定相
%K 手性拆分
%K 阿折地平
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=6E709DC38FA1D09A4B578DD0906875B5B44D4D294832BB8E&cid=6579068328FE643F&jid=4D81E042D77AFEC6881D14759692069C&aid=27045F741D9AE7ECD5CFF84498B2902A&yid=140ECF96957D60B2&vid=D3E34374A0D77D7F&iid=0B39A22176CE99FB&sid=1B64850025D0BBBE&eid=F9F74EC1AA08A7B9&journal_id=1000-8713&journal_name=色谱&referenced_num=1&reference_num=8