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色谱  2010 

Determination of gabapentin using capillary electrophoresis with laser-induced fluorescence detection
毛细管电泳-激光诱导荧光检测法测定抗癫痫药加巴喷丁

Keywords: 毛细管电泳-激光诱导荧光检测,加巴喷丁,4-氯-7-硝基苯并-2-氧杂-1,3-二唑,抗癫痫药

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Abstract:

A novel method for the determination of gabapentin (an antiepileptic drug) has been developed using capillary electrophoresis with laser-induced fluorescence detection (LIFD). Gabapentin was first derived by 4-chloro-7-nitrobenzofurazan (NBD-Cl) and baseline separated within 6 min with a running buffer consisting of 10 mmol/L borate sodium and 10 mmol/L sodium dodecyl sulfate (pH 9.75). The linear range of this method was 0.01~10 mg/L (r=0.9997) with the limit of detection (LOD) of 2 μg/L and the limit of quantification (LOQ) of 10 μg/L. The average recoveries were 100.2%~103.1% with the relative standard deviation (RSD) of 0.15%~1.00%. This method is fast, sensitive, accurate and reliable, and it has been used successfully for the quality assessment of gabapentin drug products.

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