%0 Journal Article
%T Determination of gabapentin using capillary electrophoresis with laser-induced fluorescence detection<br>ëϸ¹ÜµçÓ¾-¼¤¹âÓÕµ¼Ó«¹â¼ì²â·¨²â¶¨¿¹ñ²ðïÒ©¼Ó°ÍÅ綡
%A CAI Yuanli
%A YANG Jiajia
%A WANG Yufei
%A BAI Keke
%A LI Hui
%A <br>²ÌÔªÀö
%A Ñî¼×¼×
%A ÍõÓî·É
%A °×çæçæ
%A ÀîêÍ
%J É«Æ×
%D 2010
%I 
%X A novel method for the determination of gabapentin (an antiepileptic drug) has been developed using capillary electrophoresis with laser-induced fluorescence detection (LIFD). Gabapentin was first derived by 4-chloro-7-nitrobenzofurazan (NBD-Cl) and baseline separated within 6 min with a running buffer consisting of 10 mmol/L borate sodium and 10 mmol/L sodium dodecyl sulfate (pH 9.75). The linear range of this method was 0.01~10 mg/L (r=0.9997) with the limit of detection (LOD) of 2 ¦Ìg/L and the limit of quantification (LOQ) of 10 ¦Ìg/L. The average recoveries were 100.2%~103.1% with the relative standard deviation (RSD) of 0.15%~1.00%. This method is fast, sensitive, accurate and reliable, and it has been used successfully for the quality assessment of gabapentin drug products.
%K ëϸ¹ÜµçÓ¾-¼¤¹âÓÕµ¼Ó«¹â¼ì²â
%K ¼Ó°ÍÅ綡
%K 4-ÂÈ-7-Ïõ»ù±½²¢-2-ÑõÔÓ-1
%K 3-¶þßò
%K ¿¹ñ²ðïÒ©
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=6E709DC38FA1D09A4B578DD0906875B5B44D4D294832BB8E&cid=6579068328FE643F&jid=4D81E042D77AFEC6881D14759692069C&aid=25E691DA2BDD8EA88B28FB8AFF6A5E29&yid=140ECF96957D60B2&vid=D3E34374A0D77D7F&iid=59906B3B2830C2C5&sid=4206C58D935377EA&eid=01A9864A3FFB986F&journal_id=1000-8713&journal_name=É«Æ×&referenced_num=0&reference_num=17