Chiral Ion Pair Chromatography
手性离子对色谱法

A chiral counter ion dissolved in the mobile phase can be used to separate enantiomers of acids and amines. The principles and related separation variables have been reviewed. A successful enantiomeric separation is highly dependent on the features of counter ion chosen for the experiments. The most important properties of a suitable chiral reagent can be summarized as follows:(1) acid base character of counter ion;(2) hydrophobicity of counter ions;(3) presence of suitable funtional groups;(4) enantiomeric purity of counter ion, etc. It is also discussed about the influences of various chromatographic conditions and the applications of chiral ion pair chromatography.