Separation and Determination of the Ingredients of Cold Medicines by Capillary Electrophoresis with Amperometric Detection
高效毛细管电泳-安培法同时检测感冒药中的扑尔敏、扑热息痛和维生素C

Determination and separation of three ingredients--chlorphenamine maleate, acetaminophen and vitamin C in cold medicines by capillary electrophoresis with amperometric detection were carried out. The effects of detection potential and organic modifier were extensively investigated. Separation efficiency could be improved by adding 1, 2-propanediol into buffer. On optimizing condition, chlorphenamine maleate, acetaminophen and vitamin C were separated satisfactorily and eluted within 12 min. The detection limits were 0.02, 0.08 and 0.01 mg/L respectively. The ingredients in several cold medicines were detected successfully. The recoveries of the samples were 94.2%-102.8%. The method is simple, rapid and highly reliable for routine analysis.