Inhibitory effects of Phellinus baumii polysaccharide on the proliferation and invasion of HepG2 cell
鲍姆木层孔菌多糖对HepG2细胞增殖及侵袭相关能力的抑制作用

The inhibitory effects of Phellinus baumii polysaccharide PLP60-B1 on the proliferation and invasion of HepG2 cancer cells were investigated. The homogeneous Phellinus baumii polysaccharide PLP60-B1 having promoting effects on lymphocyte proliferation was obtained by ethanol precipitation and purified by DEAE-Sepharose F.F. and Sephacryl S-200. MTT assay and flow cytometry showed that PLP60-B1 inhibited cell proliferation as well as colony formation of HepG2 cells through the S-phase cell cycle arrest, and the homogeneous polysaccharide also demonstrated the remarkably inhibition of adhesion and invasion in HepG2 cells.