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Marine Drugs  2012 

Bioactive Hydroperoxyl Cembranoids from the Red Sea Soft Coral Sarcophyton glaucum

DOI: 10.3390/md10010209

Keywords: Sarcophyton glaucum, soft coral, diterpenes, cancer chemo-preventive activity

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Abstract:

A chemical investigation of an ethyl acetate extract of the Red Sea soft coral Sarcophyton glaucum has led to the isolation of two peroxide diterpenes, 11( S) hydroperoxylsarcoph-12(20)-ene ( 1), and 12( S)-hydroperoxylsarcoph-10-ene ( 2), as well as 8- epi-sarcophinone ( 3). In addition to these three new compounds, two known structures were identified including: ent-sarcophine ( 4) and sarcophine ( 5). Structures were elucidated by spectroscopic analysis, with the relative configuration of 1 and 2 confirmed by X-ray diffraction. Isolated compounds were found to be inhibitors of cytochrome P 450 1A activity as well as inducers of glutathione S-transferases (GST), quinone reductase (QR), and epoxide hydrolase (mEH) establishing chemo-preventive and tumor anti-initiating activity for these characterized metabolites.

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