%0 Journal Article
%T Bioactive Hydroperoxyl Cembranoids from the Red Sea Soft Coral Sarcophyton glaucum
%A Mohamed-Elamir F. Hegazy
%A Amira M. Gamal Eldeen
%A Abdelaaty A. Shahat
%A Fathy F. Abdel-Latif
%A Tarik A. Mohamed
%A Bruce R. Whittlesey
%A Paul W. Par¨¦
%J Marine Drugs
%D 2012
%I MDPI AG
%R 10.3390/md10010209
%X A chemical investigation of an ethyl acetate extract of the Red Sea soft coral Sarcophyton glaucum has led to the isolation of two peroxide diterpenes, 11( S) hydroperoxylsarcoph-12(20)-ene ( 1), and 12( S)-hydroperoxylsarcoph-10-ene ( 2), as well as 8- epi-sarcophinone ( 3). In addition to these three new compounds, two known structures were identified including: ent-sarcophine ( 4) and sarcophine ( 5). Structures were elucidated by spectroscopic analysis, with the relative configuration of 1 and 2 confirmed by X-ray diffraction. Isolated compounds were found to be inhibitors of cytochrome P 450 1A activity as well as inducers of glutathione S-transferases (GST), quinone reductase (QR), and epoxide hydrolase (mEH) establishing chemo-preventive and tumor anti-initiating activity for these characterized metabolites.
%K Sarcophyton glaucum
%K soft coral
%K diterpenes
%K cancer chemo-preventive activity
%U http://www.mdpi.com/1660-3397/10/1/209