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Molecules  2006 

Synthesis and Antifungal Bioactivities of 3-Alkylquinazolin- 4-one Derivatives

DOI: 10.3390/11060383

Keywords: Quinazolinone, Phase Transfer Catalyst, synthesis, antifungal activity

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Abstract:

A simple, efficient, and general method has been developed for the synthesis ofvarious 3-alkylquinazolin-4-one derivatives from quinazolin-4-one treated with alkylbromides under phase transfer catalysis condition. The structures of the compounds werecharacterized by elemental analysis, IR, 1H-NMR and 13C-NMR spectra. Title compound6-bromo-3-propylquinazolin-4-one (3h) was found to possess good antifungal activity.

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