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Molecules 2006
Synthesis and Antifungal Bioactivities of 3-Alkylquinazolin- 4-one DerivativesDOI: 10.3390/11060383 Keywords: Quinazolinone, Phase Transfer Catalyst, synthesis, antifungal activity Abstract: A simple, efficient, and general method has been developed for the synthesis ofvarious 3-alkylquinazolin-4-one derivatives from quinazolin-4-one treated with alkylbromides under phase transfer catalysis condition. The structures of the compounds werecharacterized by elemental analysis, IR, 1H-NMR and 13C-NMR spectra. Title compound6-bromo-3-propylquinazolin-4-one (3h) was found to possess good antifungal activity.
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