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Molecules 2000
Design and Synthesis of a Conformationally Rigid Mimic of the Dihydropyrimidine Calcium Channel Modulator SQ 32,926DOI: 10.3390/50300227 Keywords: Dihydropyrimidines, Biginelli reaction, isomünchnones, 1, 3-dipolar cycloaddition reactions, AM1 calculations, conformation Abstract: A conformationally rigid polyheterocycle (3) which mimics the putative receptorbound conformation of dihydropyridine-type calcium channel modulators is prepared in a seven-step reaction sequence based on a Biginelli-type cyclocondensation reaction.
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