Cellular and biochemical response in BALF of rats exposed to different concentrations of SO2
二氧化硫对大鼠肺泡细胞和肺泡灌洗液的生化效应

The Bronchoalveolar lavage cells(BALF) and the biochemical indexes in BALF were studied in the rats exposed to different concentrations of sulfur dioxide(SO_2).The results showed the numbers of alveolar macrophage were increased but its percentage decreased;Both the numbers and percentages of the neutrophils and lymphocytes increased in BALF,and they showed dose-response relationship.The pH values decreased significantly;the protein contents in BALF,the pulmonary vascular permeability index,the activities of acid phosphatase,alkaline phosphatase and Lactic dehydrogenase in BALF increased as well as the malondialdehyde contents.These cellular and biochemical indexes suggested different ways of damage of the structure and function of lung tissues and the cells.