Oxidation damage of formaldehyde inhalation on rat multiple organs
甲醛吸入染毒致大鼠多组织器官氧化损伤效应研究

To study the possible mechanisms of oxidative damages in rat multiple organs induced by gaseous formaldehyde, rat was exposed at formaldehyde concentration of 13.5?mg/m~3 for 7 days and 4 hrs per day.Results showed that formaldehyde inhalation caused the significance increase in levels of GSH,GSH-PX and MDA in peripheral of male rat blood.No significant difference could be observed for the concentration of GSH,GSH-PX,MDA and SOD in lung,liver and brain. These results indicate that the level of GSH,GSH-PX and MDA in peripheral blood may be as early exposure biomarkers of formaldehyde in inhalation pathway.