Study on mechanism of formaldehyde-induced DNA breakage and repair
甲醛致DNA断裂作用的机制及修复的研究

The Formaldehyde-induced DNA breakage, its mechanism and repair was studied with single cell gel electrophoresis (SCGE) in the experiment. The results showed that formaldehyde could induce DNA breakage at low concentration(P<0.01); the breakage could be inhibited markedly by mannitol, DMSO and SOD, which were the scavenger of ?OH and O?-2(P<0.01). But the mannitol and DMSO was more powerful than SOD. It concluded that formaldehyde could assuredly induce DNA breakage through ROS, and the breakage could be repaired completely in 90 minutes.