A COMPARATIVE STUDY ON CARCINOGENIC ACTIVITIES OF PBNA AND ITS ISOMER PANA IN ICR MICE
PBNA及其同分异构体PANA在小鼠ICR系中致癌性的比较研究

Repeated subcutaneous injection of technical PBNA, technical PANA and chemically pure PANA in DMSO solution into young adult male ICR mice induced malignant tumors 34.6%, 46.6% and 52.2%, respectively at the end of IQth experimental month with a total dose of 432mg given to each animal. No malignant tumors appeared in controls using DMSO. PANA seemed to show dose-response relationship in tumor initiation. Both tend to induce pulmonary carcinomas, with PANA also to induce carcinomas and hemangio-endotheliomas of kidneys.