Effect of Chlorimethylmercury on the Expression of c-fos and c-jun Genes in Rat Brain
氯化甲基汞对大鼠脑c-fos和c-jun基因表达的影响

To study the role of immediate early genes (IEG) c-fos and c-jun in the neurotoxic mechanism of methylmercury chloride(MMC), expression of FOS and JUN in rat brains was observed by using immuohistochemical methods. In the test group MMC (5.0mg/kg and 0.1mg/kg ) was injected into rats while in the control group normal saline was injected. The results showed that after rats exposed for 3 hours, the expression of FOS and JUN in brains was higher than those of the control rats, the results indicated that IEG could participate in the neurological toxicity induced by chlorimethylmercury.