ACID SENSITIVE MICELLAR AGGREGATES BASED ON AMPHIPHILIC BLOCK COPOLYMERS WITH PENDANT CYCLIC ORTHOESTER
含环状原酸酯侧基的两亲性嵌段共聚物及其酸敏感胶束状聚集体

Acid-sensitive polymeric micelles have great potential as carriers for target drug delivery systems.In this work,a methacrylate monomer with cyclic orthoester group,(2-ethoxy-5-methyl-1,3-dioxan-5-yl)methyl methacrylate(EDMM),was synthesized.Two acid-sensitive amphiphilic block copolymers,PEO-b-PEDMM_ 17 and PEO-b-PEDMM_ 34,were prepared by the atom transfer radical polymerization of EDMM using a PEO macroinitiator(molecular weight ca.2000 Da).The compositions and molecular weights of the two block copolyme...