STUDY ON THE DRUG RELEASE FROM POLYMER-DRUG COMPOSITES PREPARED BY RADIATION-INDUCED POLYMERIZATION AT LOW TEMPERATURE
低温辐射聚合制备聚合物药的慢释放研究

This paper reports the effect of monomer composition and drug content in the polymer-drug composite on the drug release rate. The polymer-dug were made by radiation-induced polymerization in a supercooled state at low temperature using monomers in glassy state. The major results obtained are:1. The release rate of drug such as indomethacin, whose molecular weight is large, could be controlled efficiently when the hydrophobie monomer MMA in the polymer-drug composite was increased.2. The release rate of drug such as 5-fluorouracil, whose molecular weight is small,could be controlled efficiently when the MMA and EDGMA in the polymer-drug composite were increased. 3. The release rate of 5-fluorouracil decreased with increasing ration of 5-fluorou-racil in the polymer-drug composite.4.The amount of drug reease from polymer-drug decreased with the rising of radiation dose.