%0 Journal Article
%T STUDY ON THE DRUG RELEASE FROM POLYMER-DRUG COMPOSITES PREPARED BY RADIATION-INDUCED POLYMERIZATION AT LOW TEMPERATURE<br>低温辐射聚合制备聚合物药的慢释放研究
%A YANG Yue-qi LIU Yu-ming
%A ZHAO Yin
%A SUN Shu-man
%A <br>杨月琪
%A 刘钰铭
%A 赵银
%A 孙树门
%J 高分子学报
%D 1986
%I 
%X This paper reports the effect of monomer composition and drug content in the polymer-drug composite on the drug release rate. The polymer-dug were made by radiation-induced polymerization in a supercooled state at low temperature using monomers in glassy state. The major results obtained are:1. The release rate of drug such as indomethacin, whose molecular weight is large, could be controlled efficiently when the hydrophobie monomer MMA in the polymer-drug composite was increased.2. The release rate of drug such as 5-fluorouracil, whose molecular weight is small,could be controlled efficiently when the MMA and EDGMA in the polymer-drug composite were increased. 3. The release rate of 5-fluorouracil decreased with increasing ration of 5-fluorou-racil in the polymer-drug composite.4.The amount of drug reease from polymer-drug decreased with the rising of radiation dose.
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=6E709DC38FA1D09A4B578DD0906875B5B44D4D294832BB8E&cid=6579068328FE643F&jid=15971983683C7643EE80F1CE621DEB60&aid=ABA6E2BD8E84F73C&yid=4E65715CCF57055A&iid=0B39A22176CE99FB&sid=35FC3610259C2B32&eid=117F81797AB182FC&journal_id=1000-3304&journal_name=高分子学报&referenced_num=2&reference_num=0