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过程工程学报 2007
Visual Study on the Formation of Naproxen Particles with Different Morphologies
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Abstract:
A new technology was proposed to visually study the crystallization morphologies of naproxen particles synthesized by reaction-precipitation. The effects of surfactant type and concentration, naproxen concentration and reacting temperature on the morphology and size of the synthesized naproxen particles were investigated, and the growth mechanism of particles was discussed briefly. It was found that needle-like, spherical, butterfly-like and rod-like crystals of naproxen particles could be obtained respectively in the presence of Tween-80, PVP, Karomic-90 or CMC. Naproxen concentration, surfactant concentration and reacting temperature could also influence the particle size significantly.
