Controllable Preparation and Characterization of Imiquimod-loaded Nanostructured Lipid Carriers
咪喹莫特纳米结构脂质载体的可控制备及表征

Imiquimod-loaded nanostuctured lipid carriers(IMQD-NLC)were prepared by high pressure homogenization method.The influences of surfactant,high pressure homogenization parameter and capacity loading on the preparation of IMQD-NLC were explored.Additionally,its morphology,crystalline phase,Zeta potential and release in vitro were characterized.The results show that there was a trend toward increasing the particle size of IMQD-NLC and decreasing the absolute value of Zeta potential with increasing the content of S-40 in the combined surfactant of S-40 and Span-20.Both the particle size and PI value were lower with the many cycle times,while ascending with increasing the content loading.IMQD-NLC,characterized by XRD,was amorphous.It was confirmed that burst release occurred followed by a sustaining release at pH 1 and a sustaining release at pH 5.5 in vitro for IMQD-NLC.Consequently the preparation of IMQD?NLC can be controlled by altering the conditions of preparation to realize sustained release effect.