%0 Journal Article
%T Controllable Preparation and Characterization of Imiquimod-loaded Nanostructured Lipid Carriers<br>咪喹莫特纳米结构脂质载体的可控制备及表征
%A ZHOU Hua-feng
%A MA Quan-hong
%A DING Yi
%A XIA Qiang
%A KUANG Ying-zi
%A HAO Xiao-zhen
%A GU Ning
%A <br>周华锋
%A 马全红
%A 丁艺
%A 夏强
%A 郝晓帧
%A 顾宁
%J 过程工程学报
%D 2006
%I 
%X Imiquimod-loaded nanostuctured lipid carriers(IMQD-NLC)were prepared by high pressure homogenization method.The influences of surfactant,high pressure homogenization parameter and capacity loading on the preparation of IMQD-NLC were explored.Additionally,its morphology,crystalline phase,Zeta potential and release in vitro were characterized.The results show that there was a trend toward increasing the particle size of IMQD-NLC and decreasing the absolute value of Zeta potential with increasing the content of S-40 in the combined surfactant of S-40 and Span-20.Both the particle size and PI value were lower with the many cycle times,while ascending with increasing the content loading.IMQD-NLC,characterized by XRD,was amorphous.It was confirmed that burst release occurred followed by a sustaining release at pH 1 and a sustaining release at pH 5.5 in vitro for IMQD-NLC.Consequently the preparation of IMQD?NLC can be controlled by altering the conditions of preparation to realize sustained release effect.
%K imiquimod
%K nanostructured lipid carriers
%K sustained release<br>咪喹莫特
%K 纳米结构脂质载体
%K 缓释
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=5B3AB970F71A803DEACDC0559115BFCF0A068CD97DD29835&cid=3FCF8B1A330466D5&jid=B9EE12934D19905403D996AE65CEEEED&aid=426C5102A21ECDF0&yid=37904DC365DD7266&vid=B31275AF3241DB2D&iid=E158A972A605785F&sid=4720E9D07E8A2290&eid=3B2BF7AC5674E8E2&journal_id=1009-606X&journal_name=过程工程学报&referenced_num=1&reference_num=10