Preliminary Evaluation of the Thromboresistance of ZnO Nanoparticles
ZnO纳米材料抗凝血性能的初步评价

Evaluation of antithrombogenicity of ZnO nanoparticles was carried out based on the measurements of in vitro kinetic clotting time. The average size of the ZnO nanoparticles was 10~30 nm. The research was divided into the control group (1 ml of whole blood), the non-nanoparticles group (1 ml of whole blood, including 0.4 ml of the stirred plasma), the ZnO group (1 ml of whole blood, including 0.4 ml of the stirred plasma and 1 mg of ZnO nanoparticles) and the Fe group (1 ml of whole blood, including 0.4 ml of the stirred plasma and 1 mg of Fe nanoparticles). Measurements of clotting time of every group were carried out at 5, 15, 30 and 45 min. The calculated results revealed that the thromboresistant radio was remained at 70% in 45 min in the ZnO nanoparticles group, while the radio dropped to 30% in 15 min in the control group, the non-nanoparticles group and the Fe group. The results predict that the ZnO nanoparticles have excellent thromboresistant property.